Epimedium sagittatum: (Horny Goat Weed Extract) contains icariin, a flavonol that improves function of reproductive organs and increases circulating levels of testosterone. Icariin also inhibits all three phosphodiesterase-5 (PDE5), which potentiates the sexual response in both men and women. In addition to treating low testosterone, the “testosterone mimetic properties” of icariin also act as a glucocorticoid antagonist properties, which can cause a relative increase in anabolic function. It has a long history of use for treating erectile dysfunction in Traditional Chinese Medicine.
Mucuna pruriens: (Velvet bean Extract) promotes testosterone production in humans by its action on the hypothalamus-pituitary-gonadal axis. It raises serum levels of both testosterone and LH, and decreases excessive cortisol associated with stress. The naturally occurring L-dopa in Mucuna increases libido and sexual behaviour, and decreases prolactin levels, which is significant because hyperprolactinemia is a major neuroendocrine-related cause of reproductive disturbances in both men & women. Mucuna improves fertility in both genders.
Tribulus terrestris: (Gokhru fruit Extract) promotes testosterone production within 10 days when taken my athletes in one study. As well as testosterone, Tribulus terrestris also increases other androgens such as dihydrotestosterone (DHT) and dehydroepiandrosterone sulphate, and cause an increase in androgen receptors, similar to the affect of testosterone. It increases sexual function in both men and women. It has gonadotropin-like activity that can increase the number of corpora lutea, primary and secondary follicles while significantly decreasing the number of ovarian cysts.
Lepidium meyenii: (Maca root) is a potent testosterone mimetic that improves sexual function in both men and women independent of testosterone or estrogen activity. Lepidium can also enhance fertility in both genders. As a cruciferous vegetable, Lepidium meyenii may provides benefits associated with consumption of cruciferous vegetables, such as a reduced risk of prostate cancer, as well as estrogen sensitive cancers in women. Maca can decrease risks of prostate disorders in men receiving testosterone replacement therapy. Maca is also anabolic and immuno-enhancing.
Turnera diffusa: (Damiana leaf) is a functional mimetic of testosterone and acts as a sexual stimulant within having androgen properties, or binding to testosterone receptors. Damiana enhances engorgement of erectile tissue due to its affect on nitric oxide pathways. It can significantly reduce the post-ejaculatory interval. The anxiolytic flavone apigenin may participate in its pro-sexual effect. Damiana is also considered to have adaptogen that can help with stress adaptation.
Ptychopetalum olacoides: (Muira Puama bark) mimics testosterone function by increasing sexual desire
& sexual function in both genders by relaxation of penile cavernous smooth muscle or clitoral cavernous smooth muscle to support penile erection or clitoral engorgement. It prevents stress induced increase of corticosterone, indicating glucocorticoid antagonist properties, which may contribute to a relative increase in anabolic function. Muira Puama also facilitates memory retrieval and improves cognitive function, due to antioxidant and acetylcholinesterase inhibitory properties.
Eleutherococcus senticosus: (Eleutherococcus senticosus root Extract) is best described as a functional mimetic of testosterone in that it mimics a number of testosterone functions, but does not bind to androgen receptors. Some of these actions include; anti-fatigue action, enhanced recovery of stress, inhibit stress induced corticosterone elevation, glycogen sparing metabolism, enhanced endurance capacity, elevated cardiovascular function, and improvement of sperm motility. It increases nitric oxide, improving sexual function in both genders.
Eurycoma longifolia: (Tongkat Ali 100:1 Extract) promotes testosterone production with a significant increase of plasma testosterone level in human studies as well as animal studies. The proandrogenic effects of Eurycoma longifolia were potent enough that it could be used as an alternative treatment to testosterone replacement therapy, or with low-dose testosterone, to treat male osteoporosis without causing the side effects associated with full-dose testosterone replacement therapy. It also has aromatase inhibiting properties that improve testosterone function.
Panax Ginseng: (Panax ginseng root Extract) promotes testosterone production. Male patients showed an increase in spermatozoa number and motility, an increase in total and free testosterone, DHT, FSH and LH levels, and a decrease in PRL. Panax improves sexual function in both genders. Panax may decrease risks of prostate disorders in men receiving testosterone replacement therapy. Panax ginseng can decrease prolactin secretion, increase nitric oxide release in sexual activity, has anabolic activity and decrease stress associated rises in cortisol.
Withania somnifera: (Ashwagandha root Extract) promotes testosterone production, causing increased serum testosterone & luteinizing hormone and decreases high levels of prolactin. Its gonadotrophic affects improve both spermatogenic activity and folliculogenesis function with increased ovarian weight, improving gonadal function in both genders. However, it also inhibits growth of some human breast cancer cells.
Withania also increases stress tolerance, oxide production, dopaminergic activity, anabolic activity and decreases stress associated rises in cortisol.