EC: 1.14.15.6
CYP11A1
Pathway: Cholesterol --> Pregnenolone
Reaction: Cholesterol + reduced adrenal ferredoxin + O(2) <=> pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H(2)O. The reaction proceeds in three stages, with hydroxylation at C-20 and C-22 preceding scission of the side-chain at C-20.
Cofactors: Iron (PMID: 16434543)
Inhibitors: aminogluthetimide (PMID: 12911631); methoxychlor (PMID: 8431464)
Enzyme Synonyms: cholesterol monooxygenase (side-chain-cleaving); cholesterol desmolase; cytochrome P-450scc (cholesterol side-chain cleavage); desmolase, steroid 20-22; C27-side chain cleavage enzyme; cholesterol 20-22-desmolase; cholesterol C20-22 desmolase; cholesterol side-chain cleavage enzyme; cholesterol side-chain-cleaving enzyme; enzymes, cholesterol side-chain-cleaving; steroid 20-22 desmolase; steroid 20-22-lyase