Anticancer actions of Bacopa monnieri by Joseph J Collins, RN, ND

Compounds in Bacopa can significantly inhibited human breast cancer cell line MDA-MB-231 adhesion, migration and invasion [1], thereby decreasing the growth, spread, and metastasis of breast cancer. Bacoside A, the active constituent of Bacopa monniera, can also be effective in preventing some forms of liver cancer [2]. Bacopa monniera extracts cause apoptosis (programmed cells death) of sarcomas in animal studies of cancer [3], [4].

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References

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[1] Peng L, Zhou Y, Kong de Y, Zhang WD. Antitumor activities of dammarane triterpene saponins from Bacopa monniera. Phytother Res. 2010 Jun;24(6):864-8. doi: 10.1002/ptr.3034. PubMed PMID: 9960417.

[2] Janani P, Sivakumari K, Geetha A, Ravisankar B, Parthasarathy C. Chemopreventive effect of bacoside A on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats. J Cancer Res Clin Oncol. 2010 May;136(5):759-70. doi: 10.1007/s00432-009-0715-0. Epub 2009 Nov 15. PubMed PMID: 19916024.

[3] Rohini G, Devi CS. Bacopa monniera extract induces apoptosis in murine sarcoma cells (S-180). Phytother Res. 2008 Dec;22(12):1595-8. doi: 10.1002/ptr.2515. PubMed PMID: 19067376.

[4] Rohini G, Sabitha KE, Devi CS. Bacopa monniera Linn. extract modulates antioxidant and marker enzyme status in fibrosarcoma bearing rats. Indian J Exp Biol. 2004 Aug;42(8):776-80. PubMed PMID: 15573526.