AdrenoMend™ a Hormone Specific™ Formulation
The primary functions of AdrenoMend™ are to overcome fatigue disorders by restoring normal function of the adrenal glands and restoring normal stress response to the other systems affected by stress.

MORE INFORMATION on the Constituents of AdrenoMend™

Schisandra chinensis helps regulate homeostasis and restore adrenal health by its action on the hypothalamic-pituitary-adrenocortex (HPA) axis and the sympathoadrenal system (SAS). It supports the neuroendocrine-immune (NEI) system, reduction-oxidation system (REDOX) and the brain monoaminergic system (BMS). Schisandra chinensis also improves cellular signaling systems (CSS) function through its action on glucocorticoid receptors as well, as the messenger proteins hsp 25 & hsp 70 and supports hepatic detoxification system (HDS) function through various mechanisms including facilitation of glutathione regeneration.

Bacopa monniera improves adrenal function through its action on the hypothalamic-pituitary-adrenocortex (HPA) axis, the sympathoadrenal system (SAS) and the brain monoaminergic system (BMS) by normalization of stress induced alteration in plasma corticosterone as well as levels of other adrenal and brain monoamines. It has a thyroid stimulating role, enhancing the function of the hypothalamic-pituitary-thyroid (HPT) axis. Bacopa monniera also has hepato-protective properties that support the hepatic detoxification system (HDS), and adapts the cellular signaling systems (CSS) by modulating hsp70 (a messenger protein). It also supports reduction-oxidation system (REDOX) by affecting super-oxide dismutase and catalase activity.

Rhodiola rosea promotes recovery from adrenal fatigue by modulating (adapting) how the sympathoadrenal system (SAS) and the hypothalamic-pituitary-adrenocortex (HPA) axis each respond to acute stress. It also protect tissue from the effect of excessive adrenalin sympathoadrenal system (SAS), & brain monoaminergic system (BMS). It supports normal homeostasis of the neuroendocrine-immune (NEI) system, and supports the hepatic detoxification system (HDS) through its hepatoprotective properties. Rhodiola rosea also decreases stress induced changed in the hypothalamic-pituitary-thyroid (HPT) axis and the glucose-insulin system (GIS), as well as the renin-angiotensin-aldosterone system (RAAS). It also support the reduction-oxidation system (REDOX) by increasing the activity of various antioxidant enzymes, including liver Mn-superoxide dismutase Cu/Zn-superoxide dismutase, and catalase, which provide hepatoprotective activity and support the and hepatic detoxification system (HDS).

Eleutherococcus senticosus improves hypothalamic-pituitary-adrenocortex (HPA) axis function by modulating (adapting) corticosterone elevation induced by stress affecting both the hypothalamic-pituitary-adrenocortex (HPA) axis and renin-angiotensin-aldosterone system (RAAS) homeostasis. It can protect tissues from the effect of excessive adrenalin, thereby modulating the effects of the sympathoadrenal system (SAS). It supports the reduction-oxidation system (REDOX) through its strong antioxidant activity. Eleutherococcus senticosus displays hepatoprotective properties against heavy metals, hepatotoxins and bacterial endotoxins, which supports the hepatic detoxification system (HDS). Eleutherococcus senticosus improves function of the glucose-insulin system (GIS), restores normal function of the cellular signaling systems (CSS) through its affect on hormone receptors, muscarinic receptors, acetylcholine activity, and nitric oxide activity, which can amplify tissue response to testosterone, supporting activity of the hypothalamic-pituitary-gondal (HPG) axis. Eleutherococcus senticosus also restores homeostatic function of the neuroendocrine-immune (NEI) system.

Magnolia officinalis can reduce elevated corticosterone concentrations and normalize the (hypothalamic-pituitary-adrenocortex (HPA) axis as well. It also normalizes the sympathoadrenal system (SAS) the brain monoaminergic system (BMS), and the sympathoadrenal system (SAS). Magnolia officinalis supports the reduction-oxidation system (REDOX) through its strong antioxidant activity. The neuroendocrine-immune (NEI) system and hepatic detoxification system (HDS) are also supported, as well as the ghrelin-leptin-adiponectin system (GLAS).

Rehmannia glutinosa restores homeostasis to the hypothalamic-pituitary-adrenocortex (HPA) axis and restores cellular signaling systems (CSS) function through normalization of glucocorticoid receptors. Normal glucose-insulin system (GIS) function is restored. The brain monoaminergic system (BMS) is supported. Rehmannia glutinosa can increase total antioxidant capability, glutathione content, and superoxide dismutase and catalase activities and support the reduction-oxidation system (REDOX). It is hepatoprotective and restores hepatic antioxidants and reduces liver malondialdehyde, a marker of oxidative stress, supporting the hepatic detoxification system (HDS). Rehmannia glutinosa also restores homeostasis to renin-angiotensin-aldosterone system (RAAS) by inhibiting over-expression of angiotensin II.

Bupleurum falcatum promotes adrenal recovery through its action on hypothalamic-pituitary-adrenocortex (HPA) axis mediated release of adrenocorticotropic hormone. It also supports normal neuroendocrine-immune (NEI) system function, brain monoaminergic system (BMS) function, and the hepatic detoxification system (HDS), as well as the ghrelin-leptin-adiponectin system (GLAS). Bupleurum falcatum enhances the activity of reactive oxygen species scavengers (superoxide dismutase, catalase, glutathione peroxidase), supporting the reduction-oxidation system (REDOX) in scavenging oxygen-free radicals

Panax ginseng promotes homeostasis of the sympathoadrenal system (SAS) and hypothalamic-pituitary-adrenocortex (HPA) axis, as well as the hypothalamic-pituitary-gondal (HPG) axis and the hypothalamic-pituitary-thyroid (HPT) axis. In addition, it supports the brain monoaminergic system (BMS), glucose-insulin system (GIS), the renin-angiotensin-aldosterone system (RAAS), and the ghrelin-leptin-adiponectin system (GLAS). Panax ginseng enhances superoxide dismutase, glutathione peroxidase and catalase activity, supporting the reduction-oxidation system (REDOX) in scavenging oxygen-free radicals. It can support the hepatic detoxification system (HDS) by protecting liver mitochondria from hypoxic damage, reducing the toxic effect of cadmium, and maintaining of reduced glutathione levels and glutathione s-transferase activity, while preventing increases in the alanine aminotransferase and aspartate aminotransferase levels when challenged with hepatoxins.

Coleus forskohlii (aka Plectranthus barbatus & Coleus barbatus) protects tissues from the effect of excessive adrenalin from the sympathoadrenal system (SAS). It also supports hypothalamic-pituitary-thyroid (HPT) axis, hypothalamic-pituitary-adrenocortex (HPA) axis, and hypothalamic-pituitary-gondal (HPG) axis function. In addition, glucose-insulin system (GIS), neuroendocrine-immune (NEI) system, and ghrelin-leptin-adiponectin system (GLAS)] function are supported. Detoxification and hepatoprotective support of the hepatic detoxification system (HDS) appears to be due to its protective effect against biliary cirrhosis, inhibition of fatty liver, and increased liver mitochondrial glutathione S-transferase isoform alpha-4, a phase II detoxification enzyme. It is also observed to have some antioxidant activity, which can support the reduction-oxidation system (REDOX).

Withania somnifera can modulate the sympathoadrenal system (SAS) and hypothalamic-pituitary-adrenocortex (HPA) axis responses to stress. It supports the actions of the hypothalamic-pituitary-thyroid (HPT) axis by enhancing thyroid function and supporting conversion towards T3 and away from rT3, and potentially ameliorates metformin-induced hypothyroidism in Type 2 diabetic subjects. Withania somnifera supports cellular signaling systems (CSS) through its affect on nitric acid synthase, allowing for increase nitric oxide production by macrophages, supporting neuroendocrine-immune (NEI) system function. It increases the activity of antioxidant enzymes such as superoxide dismutase and catalase, supporting the reduction-oxidation system (REDOX) in scavenging oxygen-free radicals. Withania somnifera supports the system (HDS) by activating phase II and antioxidant enzymes in the liver including glutathione S-transferase, catalase, and superoxide dismutase, and through hepatoprotection against heavy metals and toxins. It also supports hypothalamic-pituitary-gondal (HPG) axis function, as well as brain monoaminergic system (BMS) [ws4,5] function. Withania somnifera can support the glucose-insulin system (GIS) by normalizing hyperglycemia by decreasing blood glucose and improving insulin sensitivity. In addition, it can support the renin-angiotensin-aldosterone system (RAAS) by increasing urine sodium and urine volume.


AdrenoMend™ is a synergistic combination of ten highly valued herbal extracts with adaptogenic properties designed to support healthy, balanced adrenal gland function. These plant adaptogens include Schisandra chinensis, Bacopa monnieri, Rhodiola rosea, Eleutherococcus senticosus, Magnolia officinalis, Rhemannia glutinosa, Bupleurum falcatum, Panax ginseng, Coleus forskohlii and Withania sominfera.
The response to chronic stress - first defined as occurring in three stages by Hans Selye as alarm, resistance and exhaustion - typically results in aberrant adrenal function and adrenal fatigue, as well as abnormal cognitive, metabolic, energy, endurance, immune and glycemic function. The consequences of intermittent stress, or episodic acute stress during resistance or exhaustion, interfere with recovery and also promote abnormal neuro- endocrine, metabolic and immune system function.
Both acute and chronic stress are effectively address by the plant adaptogens in AdrenoMend™, which address all stages of stress and supports the body’s ability to adapt to stressors and help avoid the damaging consequences from those stressors.
Collectively, plant adaptogens can support symptoms of fatigue and enhance endurance as well as support normal mental and emotional well being. Plant adaptogens also can increase the body's ability to resist and recover from stress while providing an overall feeling of balance and normalization.
During acute stress, and the alarm stage of stress, Rhodiola rosea, Schizandra chinensis, Bacopa monnieri, and Eleutherococcus senticosus can support mental performance and physical working capacity, as well as promote the balanced response of the sympatho-adrenal-system (SAS) to the bodys acute reaction to a stressor.
During the resistance stage Withania somnifera, Coleus forskohlii, are able to support the normal thyroid and gonadal. function. In the exhaustion stage the Rehmannia glutinosa, Bupleurum falcatum and Withania somnifera act as primary agents to restore proper function of the hypothalamic-pituitary-adrenal axis and work synergistically with other plant adaptogens to support normal function of other body systems. Adaptogens with adrenotrophic properties may also decrease adrenal atrophy seen in the exhaustion stage of chronic stress.
The increased cortisol levels seen in various stages of stress are modulated by Schizandra chinensis and Magnolia officinalis. Rehmannia glutinosa can help restore normal function of glucocorticoid receptors that have been down regulated due to chronically elevated levels of cortisol. Bupleurum falcatum supports adrenal recovery and normalization of the hypothalamicpituitary- adrenal (HPA) system by promoting the release of adrenocorticotropic hormone (ACTH), which is responsible for maintaining the normal size and function of the adrenal gland.
Stress induced elevations of catecholamines and adrenaline-induced hyperglycemia can be modulated by Magnolia officinalis, Panax ginseng and Rehmannia glutinosa.
While the primary benefit of plant adaptogens is the ability to restore healthy, balanced adrenal gland function by supporting normal hypothalamic-pituitary-adrenal (HPA) axis function, the effectiveness of these adaptogens is in large part also due to their ability to protect and promote the recovery of neuro-cognitive, neuromuscular, cardiovascular, glycemic, hepatic, thyroid, gonadal and immune system health.

AdrenoMend™ is formulated by Dr. Joseph J. Collins, RN, ND and manufactured and distributed by Douglas Laboratories®

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AdrenoMend References

120 Vegetarian Capsules
  • Hypothalamic-Pituitary-Adrenocortical (HPA) axis
  • Sympatho-Adrenomedullary System (SAS
In addition, AdrenoMend™ rebalances the function of the other homeostasis regulatory systems involved in the stress response. While the adrenal glands play a major role is responding to the demands of stress, the adrenal glands are not the only part of the body affected by stress. The additional homeostasis regulatory systems involved in the stress response include:
  • Hypothalamic-Pituitary-Gonadal (HPG) axis
  • Hypothalamic-Pituitary-Thyroid (HPT) axis
  • Neuro-Endocrine-Immune (NEI) system
  • Glucose-Insulin System (GIS)
  • Brain Monoaminergic System (BMS)
  • Renin-Angiotensin-Aldosterone System (RAAS)
  • Hepatic Detoxification System (HDS)
  • Cellular Signaling Systems (CSS)
  • REDuction-OXidation System (REDOX)
  • Ghrelin-Leptin-Adiponectin System (GLAS)
This is accomplished by first directly rebalancing the function of the two homeostasis regulatory systems directly involved in adrenal gland function: