3beta-hydroxy-DELTA5-steroid dehydrogenase

EC: 1.1.1.145
Pathways: Pregnenolone --> Progesterone

17-hydroxy-pregnenolone --> 17 hydroxy- progesterone

Dehydroepiandrosterone --> Androstenedione

Androstenediol --> Testosterone

Reaction: A 3-beta-hydroxy-Delta(5)-steroid + NAD(+) <=> a 3-oxo-Delta(5)-steroid + NADH. Acts on 3-beta-hydroxyandrost-5-en-17-one to form androst-4-ene-3,17- dione and on 3-beta-hydroxypregn-5-en-20-one to form progesterone.
Cofactors: NAD+ (PMID: 6957697)
Inhibitors: gossypol (PMID: 19429456); apigenin (PMID: 15084349); Biochanin A (PMID: 15084349; PMID: 16023337); daidzein (PMID: 15084349); cadmium (PMID: 6957697); Copper (PMID: 6957697)
Enzyme Synonyms: 3beta hydroxysteroid dehydrogenase; 3beta-HSD; 3-beta-hydroxy-delta(5)-steroid dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase.